Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 4/20 | 0.41 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 2/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946983 | 0.91 | CASR (0.43) | CASRACACBCNR1KDM4EALDH1A1 | |
| SCHEMBL3942465 | 0.90 | CASR (0.41) | CASRACACBCNR1KDM4EMEN1 | |
| SCHEMBL3945390 | 0.89 | CASR (0.42) | CASRCNR1KDM4EALDH1A1MEN1 | |
| SCHEMBL4036518 | 0.89 | CASR (0.40) | CASRCNR1KDM4EALDH1A1PTGDR2 | |
| SCHEMBL3952113 | 0.88 | CASR (0.44) | CASRACACBCNR1ALDH1A1 | |
| SCHEMBL3942446 | 0.84 | CASR (0.41) | CASRACACBCNR1RPS6KB1 | |
| SCHEMBL3947316 | 0.84 | CASR (0.41) | CASRCNR1MEN1KMT2ARPS6KB1 | |
| SCHEMBL3951654 | 0.83 | CASR (0.41) | CASRCNR1PTGDR2MEN1KMT2A | |
| SCHEMBL3951537 | 0.83 | CASR (0.46) | CASRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL3945231 | 0.82 | HPGD (0.40) | CASRKDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |