Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 3/20 | 0.43 |
| ▸ | ADCY6 | O43306 | 2/20 | 0.43 |
| ▸ | ADCY3 | O60266 | 2/20 | 0.43 |
| ▸ | ADCY9 | O60503 | 2/20 | 0.43 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.43 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.43 |
| ▸ | ADCY7 | P51828 | 2/20 | 0.43 |
| ▸ | ADCY2 | Q08462 | 2/20 | 0.43 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.43 |
| ▸ | ADCY4 | Q8NFM4 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3271868 | 0.87 | EPHX1 (0.51) | EPHX1GCGRADCY6ADCY3ADCY9 | |
| SCHEMBL4027743 | 0.87 | ESR1 (0.58) | EPHX1ESR1ESR2LMNA | |
| SCHEMBL5175445 | 0.86 | CNR1 (0.48) | EPHX1MEN1CYP1A2CYP2C19KMT2A | |
| SCHEMBL5176814 | 0.86 | EPHX1 (0.50) | EPHX1GCGRADCY6ADCY3ADCY9 | |
| SCHEMBL3273907 | 0.86 | EPHX1 (0.50) | EPHX1MEN1KMT2AGCGRADCY6 | |
| SCHEMBL3277794 | 0.85 | EPHX1 (0.43) | EPHX1GCGRADCY6ADCY3ADCY9 | |
| Hydrochloric Acid SCHEMBL4026086 | 0.84 | EPHX1 (0.49) | EPHX1MEN1KMT2AGCGRADCY6 | |
| SCHEMBL3276785 | 0.84 | ICMT (0.48) | EPHX1MEN1CYP1A2CYP2C19KMT2A | |
| Hydrochloric Acid SCHEMBL3950180 | 0.84 | EPHX1 (0.42) | EPHX1GCGRADCY6ADCY3ADCY9 | |
| SCHEMBL3939264 | 0.84 | EPHX1 (0.49) | EPHX1MEN1KMT2AGCGRADCY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-A2 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | Cadila Healthcare Limited (IN) | 2009-04-22 | — | — | EP | claimed |
| WO-2008059513-A2 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LIMITED (IN) | 2008-05-22 | — | — | WO | claimed |
| US-20090171091-A1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LIMITED (IN) | 2009-07-02 | — | — | US | disclosed |
| EP-2049493-A2 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | Cadila Healthcare Limited (IN) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008059513-A2 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LIMITED (IN) | 2008-05-22 | — | — | WO | disclosed |
| US-7259183-B2 | Indole, indazole and indoline derivatives as CETP inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2007-08-21 | — | — | US | disclosed |
| EP-1776338-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-04-25 | — | — | EP | disclosed |
| US-20060030613-A1 | Indole, indazole and indoline derivatives as CETP inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | US | disclosed |
| WO-2006013048-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030613-A1 | Indole, indazole and indoline derivatives as CETP inhibitors | CETP, NAT1, MTTP | EPHX1 2381/4885MEN1 2604/4885CYP1A2 156/4885 |
| US-20090171091-A1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CETP, APOB, HDLBP | EPHX1 1260/4885MEN1 1778/4885CYP1A2 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.