Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3951160 | 0.95 | MEN1 (0.64) | TP53TSHRMAPK1MEN1KMT2A | |
| SCHEMBL3950394 | 0.83 | MEN1 (0.56) | TP53TSHRMEN1KMT2AMAPT | |
| SCHEMBL3947142 | 0.82 | MEN1 (0.53) | TP53TSHRMEN1KMT2ATHRB | |
| SCHEMBL3943138 | 0.81 | RXFP1 (0.55) | MEN1KMT2AALDH1A1 | |
| SCHEMBL13942605 | 0.81 | TSHR (0.52) | TP53TSHRMEN1KMT2AMAPT | |
| SCHEMBL13942611 | 0.79 | MEN1 (0.51) | TP53TSHRMEN1KMT2AMAPT | |
| SCHEMBL10113258 | 0.78 | TSHR (0.75) | TP53TSHRMAPK1MEN1KMT2A | |
| SCHEMBL19752712 | 0.77 | MEN1 (0.67) | TP53MEN1KMT2AMAPTTHRB | |
| SCHEMBL19752713 | 0.77 | MEN1 (0.67) | TP53MEN1KMT2AMAPTTHRB | |
| SCHEMBL3944408 | 0.76 | TSHR (0.49) | TP53TSHRMAPK1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |