Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 8/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 7/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 8/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 7/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 6/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.36 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.36 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | BHMT | Q93088 | 1/20 | 0.35 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25661099 | 0.87 | NOS3 (0.47) | GRIK1GRIK2SLC7A5TDP1NOS3 | |
| SCHEMBL25660421 | 0.87 | NOS3 (0.47) | GRIK1GRIK2SLC7A5TDP1NOS3 | |
| SCHEMBL3184294 | 0.78 | SLC7A5 (0.55) | GRIK1GRIK2SLC7A5SLC1A2SLC1A1 | |
| SCHEMBL3184300 | 0.78 | SLC7A5 (0.55) | GRIK1GRIK2SLC7A5SLC1A2SLC1A1 | |
| SCHEMBL8196074 | 0.77 | GSR (0.46) | GRIK1GRIK2NOS3NOS1NOS2 | |
| SCHEMBL15723460 | 0.76 | TDP1 (0.49) | TDP1NOS3NOS1NOS2 | |
| SCHEMBL10521815 | 0.76 | TDP1 (0.49) | TDP1NOS3NOS1NOS2 | |
| SCHEMBL25315421 | 0.76 | GSR (0.48) | GRIK1GRIK2NOS3NOS1NOS2 | |
| SCHEMBL25318738 | 0.76 | GSR (0.48) | GRIK1GRIK2NOS3NOS1NOS2 | |
| SCHEMBL25262546 | 0.76 | GSR (0.48) | GRIK1GRIK2NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312370-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2009-12-17 | — | — | US | disclosed |
| EP-2046761-A2 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008009750-A2 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312370-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | BACE2, BACE1, APP | GRIK1 1451/4885GRIK2 1535/4885SLC7A5 291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.