Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 2/20 | 0.52 |
| ▸ | KDM4B | O94953 | 2/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.52 |
| ▸ | KDM5C | P41229 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | RRM1 | P23921 | 1/20 | 0.49 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | PHGDH | O43175 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457631 | 0.91 | MAPT (0.46) | KDM4AKDM4BKDM5BRAB9ARRM1 | |
| SCHEMBL4741397 | 0.87 | RAB9A (0.56) | KDM4AKDM4BKDM5BKDM5CRAB9A | |
| SCHEMBL13961193 | 0.83 | MTTP (0.49) | RRM1RRM2BMAPTKDM4ELMNA | |
| SCHEMBL4844171 | 0.78 | SCD (0.56) | RAB9AADORA3PHGDHMAPTPARP1 | |
| SCHEMBL4743698 | 0.78 | MEN1 (0.51) | RAB9ARRM1RRM2BADORA3MAPT | |
| SCHEMBL14102317 | 0.76 | MEN1 (0.49) | RAB9ARRM1RRM2BMAPTLMNA | |
| SCHEMBL14027877 | 0.76 | MTTP (0.55) | RAB9ARRM1RRM2BADORA3PHGDH | |
| SCHEMBL22801114 | 0.75 | RAB9A (0.51) | RAB9AMAPTKDM4ELMNAMEN1 | |
| SCHEMBL5666303 | 0.75 | MTTP (0.56) | — | |
| SCHEMBL7221399 | 0.74 | KDM4E (0.61) | RAB9AMAPTKDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014674-A1 | HETEROCYCLYLAMIDES AS GUT MICROSOMAL TRIGLYCERIDE TRANSPORT PROTEIN INHIBITORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009014674-A1 | HETEROCYCLYLAMIDES AS GUT MICROSOMAL TRIGLYCERIDE TRANSPORT PROTEIN INHIBITORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |