Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RRM1 | P23921 | 1/20 | 0.46 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM4B | O94953 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942967 | 0.91 | KDM4A (0.52) | MAPTKDM4ERRM1RRM2BADORA3 | |
| SCHEMBL4743698 | 0.87 | MEN1 (0.51) | MAPTALDH1A1THRBKDM4ERRM1 | |
| SCHEMBL13961193 | 0.80 | MTTP (0.49) | MAPTALDH1A1KDM4ERRM1RRM2B | |
| SCHEMBL4741397 | 0.78 | RAB9A (0.56) | MAPTRRM1RRM2BADORA3MAPK1 | |
| SCHEMBL22801024 | 0.76 | KMT2A (0.49) | MAPTALDH1A1THRBKDM4EADORA3 | |
| SCHEMBL14102317 | 0.73 | MEN1 (0.49) | MAPTALDH1A1RRM1RRM2BMEN1 | |
| SCHEMBL14027877 | 0.72 | MTTP (0.55) | MAPTALDH1A1RRM1RRM2BADORA3 | |
| SCHEMBL18387916 | 0.72 | ALDH1A1 (0.55) | MAPTALDH1A1THRBKDM4EADORA3 | |
| SCHEMBL27326388 | 0.72 | ALDH1A1 (0.52) | ALDH1A1KDM4ERAB9ASMN1; SMN2HTT | |
| SCHEMBL11087776 | 0.71 | ALDH1A1 (0.56) | MAPTALDH1A1THRBRRM1RRM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014674-A1 | HETEROCYCLYLAMIDES AS GUT MICROSOMAL TRIGLYCERIDE TRANSPORT PROTEIN INHIBITORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009014674-A1 | HETEROCYCLYLAMIDES AS GUT MICROSOMAL TRIGLYCERIDE TRANSPORT PROTEIN INHIBITORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |