Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20604844 | 0.83 | PIM1 (0.48) | KDM4EALDH1A1GLAGAAF10 | |
| SCHEMBL398926 | 0.82 | KDM4C (0.41) | KDM4EALDH1A1F10MAPTL3MBTL1 | |
| SCHEMBL2122533 | 0.80 | CHIA (0.43) | MAPTLMNA | |
| SCHEMBL32678014 | 0.79 | F10 (0.49) | KDM4EALDH1A1GLAGAAF10 | |
| SCHEMBL32678012 | 0.79 | F10 (0.49) | KDM4EALDH1A1GLAGAAF10 | |
| SCHEMBL32678004 | 0.79 | F10 (0.54) | KDM4EALDH1A1GLAGAAF10 | |
| SCHEMBL28697754 | 0.74 | MAPT (0.43) | KDM4EALDH1A1GLAGAAF10 | |
| SCHEMBL9911009 | 0.74 | KDM4E (0.51) | KDM4EALDH1A1GLAGAAMAPT | |
| SCHEMBL15714571 | 0.74 | MYC (0.62) | KDM4EALDH1A1GLAGAALMNA | |
| SCHEMBL19943248 | 0.72 | MAPT (0.55) | KDM4EALDH1A1GAAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408745-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-01-25 | — | — | EP | disclosed |