Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13891217 | 0.81 | F2R (0.41) | F2RKDM4EL3MBTL1MMP2HTT | |
| SCHEMBL3443638 | 0.79 | HIF1A (0.58) | ADRB3ADRB2ADRB1KDM4EL3MBTL1 | |
| SCHEMBL9647484 | 0.78 | HIF1A (0.49) | F2RFAAHADRB3ADRB2ADRB1 | |
| SCHEMBL3443553 | 0.77 | AOC3 (0.43) | ADRB3ADRB2KDM4EL3MBTL1MEN1 | |
| SCHEMBL3944328 | 0.77 | KDM4E (0.61) | F2RFAAHADRB3ADRB2ADRB1 | |
| SCHEMBL3950247 | 0.77 | AOC3 (0.43) | ADRB2KDM4EL3MBTL1GAAALDH1A1 | |
| SCHEMBL5076851 | 0.77 | KDM4E (0.67) | KDM4EL3MBTL1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2673557 | 0.77 | KDM4E (0.67) | KDM4EL3MBTL1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5073667 | 0.77 | KDM4E (0.67) | KDM4EL3MBTL1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL11980400 | 0.74 | CA12 (0.43) | F2RFAAHKDM4EL3MBTL1GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |