Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GALR3 | O60755 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944328 | 0.82 | KDM4E (0.61) | HIF1ALMNAKDM4EKMT2AF2R | |
| SCHEMBL6680502 | 0.81 | HIF1A (0.63) | HIF1ALMNAGALR3KDM4EL3MBTL1 | |
| SCHEMBL2249403 | 0.80 | LMNA (0.54) | LMNAKDM4EL3MBTL1F2RCYP19A1 | |
| SCHEMBL18245963 | 0.80 | LMNA (0.54) | LMNAKDM4EL3MBTL1F2RCYP19A1 | |
| SCHEMBL6457448 | 0.78 | HIF1A (0.66) | HIF1ALMNAGALR3KDM4EL3MBTL1 | |
| SCHEMBL3944322 | 0.78 | F2R (0.41) | HIF1AKDM4EL3MBTL1KMT2AF2R | |
| SCHEMBL2297898 | 0.77 | HIF1A (0.53) | HIF1ALMNAGALR3KDM4EL3MBTL1 | |
| SCHEMBL2294187 | 0.77 | HIF1A (0.53) | HIF1ALMNAGALR3KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL6458419 | 0.77 | HIF1A (0.63) | HIF1ALMNAGALR3KDM4EL3MBTL1 | |
| SCHEMBL2291082 | 0.77 | HIF1A (0.53) | HIF1ALMNAGALR3KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322389-B1 | NOVEL ANTIARRHYTHMIC AGENTS II | Aktiebolaget Hässle (SE) | 1992-10-28 | — | — | EP | disclosed |
| US-5034411-A | Cardiovascular disorders or antiarrhythmia agents | AKTIEBOLAGET HASSLE (SE) | 1991-07-23 | — | — | US | disclosed |
| WO-1989005795-A1 | NOVEL ANTIARRHYTHMIC AGENTS II | Aktiebolaget Hässle (SE) | 1989-06-29 | — | — | WO | disclosed |
| EP-0322389-A2 | Novel antiarrhythmic agents II | Aktiebolaget Hässle (SE) | 1989-06-28 | — | — | EP | disclosed |