Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | BCR | P11274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3545008 | 0.96 | MEN1 (0.33) | MEN1KMT2ACTSLCTSBCTSS | |
| SCHEMBL3542118 | 0.88 | MEN1 (0.33) | MEN1KMT2ACTSLCTSBCTSS | |
| SCHEMBL3934658 | 0.85 | ABL1 (0.33) | MEN1KMT2AABL1BCR | |
| SCHEMBL3546180 | 0.83 | MEN1 (0.43) | MEN1KMT2A | |
| SCHEMBL3537452 | 0.80 | ABL1 (0.35) | MEN1KMT2AABL1BCR | |
| SCHEMBL3539558 | 0.79 | HDAC3 (0.38) | MEN1KMT2AABL1BCR | |
| SCHEMBL3543306 | 0.78 | CRHR1 (0.35) | MEN1KMT2A | |
| SCHEMBL3542239 | 0.78 | MEN1 (0.34) | MEN1KMT2AABL1BCR | |
| SCHEMBL3538730 | 0.77 | ABL1 (0.33) | MEN1KMT2AABL1BCR | |
| SCHEMBL3546883 | 0.74 | HSD17B1 (0.37) | ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |