Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944885 | 0.88 | GAA (0.54) | MAOBNPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL11073323 | 0.85 | HCAR2 (0.49) | RAB9AMAPTKDM4EALDH1A1TDP1 | |
| SCHEMBL3944122 | 0.83 | RAB9A (0.47) | NPC1RAB9AMAPTHDAC1HDAC6 | |
| SCHEMBL3941686 | 0.83 | RAB9A (0.52) | NPC1RAB9AMAPTHDAC1HDAC6 | |
| SCHEMBL13941765 | 0.82 | APP (0.49) | MAOBRAB9AKDM4EMMP1MMP2 | |
| SCHEMBL7080205 | 0.82 | TAAR1 (0.49) | MAOBMRGPRX4MEN1KMT2A | |
| SCHEMBL11066194 | 0.81 | NPC1 (0.46) | MAOBNPC1RAB9AMAPTKDM4E | |
| SCHEMBL28212223 | 0.81 | NPC1 (0.54) | NPC1RAB9AMTNR1AMTNR1BMEN1 | |
| SCHEMBL3951209 | 0.78 | CYP3A4 (0.51) | NPC1RAB9AMAPTMEN1ALDH1A1 | |
| SCHEMBL7332474 | 0.78 | TAAR1 (0.61) | RAB9AHDAC1HDAC6MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |