Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | LIG1 | P18858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16161550 | 0.91 | SMN1; SMN2 (0.49) | HPGDTSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL26731689 | 0.89 | CA1 (0.50) | HPGDTSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL14172740 | 0.89 | KDM4E (0.60) | HPGDTSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL1482988 | 0.84 | ALDH1A1 (0.68) | HPGDTSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL29690311 | 0.84 | ALDH1A1 (0.68) | HPGDTSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL1628363 | 0.83 | TSHR (0.50) | HPGDTSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL23748226 | 0.81 | ALDH1A1 (0.46) | HPGDTSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL16149262 | 0.81 | ERN1 (0.44) | HPGDTSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL30593089 | 0.81 | ALDH1A1 (0.46) | HPGDTSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL11293049 | 0.81 | CXCR5 (0.43) | HPGDTSHRMAPK1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | THE UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-12-31 | — | — | US | disclosed |
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | THE UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-12-31 | — | — | US | disclosed |
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | THE UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-12-31 | — | — | US | disclosed |
| EP-2046768-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | Kudos Pharmaceuticals Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008009934-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008009934-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326223-A1 | SYNTHESIS OF 2-AMINO-SUBSTITUTED 4-OXO-4H-CHROMEN-8.YL-TRIFLUORO-METHANESULFONIC ACID ESTERS | XRN2, ASNS, CYP2B6 | HPGD 2681/4885TSHR 1437/4885MAPK1 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.