SCHEMBL3944798

SCHEMBL3944798

[c]1ncccc1Nc1ccccc1-c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FABP3 P05413 1/20 0.42
FABP4 P15090 1/20 0.42
FABP5 Q01469 1/20 0.42
KDM4E B2RXH2 1/20 0.37
ATM Q13315 1/20 0.37
ADRA2A P08913 3/20 0.36
ADRA2C P18825 3/20 0.36
ADRA2B P18089 2/20 0.36
MAOA P21397 2/20 0.36
MAOB P27338 2/20 0.36
ADRA1A P35348 2/20 0.36
ADRA1D P25100 1/20 0.36
AURKA O14965 1/20 0.36
ALDH1A1 P00352 2/20 0.35
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
CDC25B P30305 1/20 0.35
MYC P01106 2/20 0.35
METAP2 P50579 2/20 0.35
HTR7 P34969 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8582933 0.75
SCHEMBL70760 0.74 HSD17B10 (0.44) KDM4EATMAURKAALDH1A1ALOX15
SCHEMBL2437912 0.73 FABP3 (0.67) FABP3FABP4FABP5ALDH1A1CDC25B
SCHEMBL29574036 0.73 FABP3 (0.67) FABP3FABP4FABP5ALDH1A1CDC25B
SCHEMBL15605284 0.71 FABP3 (0.64) FABP3FABP4FABP5ALDH1A1CDC25B
SCHEMBL15401372 0.70 FABP3 (0.46) FABP3FABP4FABP5KDM4EATM
SCHEMBL5370631 0.69 FABP3 (0.62) FABP3FABP4FABP5ALDH1A1CDC25B
SCHEMBL16616585 0.69 FABP3 (0.62) FABP3FABP4FABP5ALDH1A1CDC25B
SCHEMBL27703626 0.69 AURKA (0.49) FABP3FABP4FABP5KDM4EATM
SCHEMBL17969646 0.69 NTRK1 (0.49) FABP3FABP4FABP5KDM4EATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7521004-B2 Chromene compound TOKUYAMA CORPORATION (JP) 2009-04-21 US disclosed
EP-1674460-B1 CHROMENE COMPOUND TOKUYAMA CORP (JP) 2009-01-21 EP disclosed
US-20070215844-A1 Chromene Compound TOKUYAMA CORPORATION (JP) 2007-09-20 US disclosed
EP-1674460-A1 CHROMENE COMPOUND Tokuyama Corporation (JP) 2006-06-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070215844-A1 Chromene Compound CRY2, TYR, CRY1 FABP3 4616/4885FABP4 4387/4885FABP5 3241/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.