Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.75 |
| ▸ | HPGD | P15428 | 6/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | CA12 | O43570 | 1/20 | 0.75 |
| ▸ | CA1 | P00915 | 1/20 | 0.75 |
| ▸ | CA2 | P00918 | 1/20 | 0.75 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.75 |
| ▸ | CA4 | P22748 | 1/20 | 0.75 |
| ▸ | CA6 | P23280 | 1/20 | 0.75 |
| ▸ | CA7 | P43166 | 1/20 | 0.75 |
| ▸ | CA9 | Q16790 | 1/20 | 0.75 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.75 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | G6PD | P11413 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL31133630 | 0.87 | ALDH1A1 (0.70) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL17156443 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29360246 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1509155 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1967 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29362663 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29606432 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL8433746 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL299754 | 0.84 | ALDH1A1 (0.95) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL5183939 | 0.84 | ALDH1A1 (0.95) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103772083-A | Carboxylic ester preparation method | UNIV SICHUAN | 2014-05-07 | — | — | CN | disclosed |
| CN-1834090-B | Benzimidazole compounds, its preparation and uses | SHANGHAI INST MATERIA MEDICA | 2011-06-29 | — | — | CN | disclosed |
| CN-101600704-A | Whitfield's ointment thiophene methyl esters and relevant compound as spices and essence | FLEXITRAL INC (US) | 2009-12-09 | — | — | CN | disclosed |
| EP-2046772-A1 | THIOPHENEMETHYL SALICYLATE AND RELATED COMPOUNDS AS FLAVOURS AND FRAGRANCES | Flexitral, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008009914-A1 | THIOPHENEMETHYL SALICYLATE AND RELATED COMPOUNDS AS FLAVOURS AND FRAGRANCES | FLEXITRAL, INC. (US) | 2008-01-24 | — | — | WO | disclosed |
| CN-1849368-A | Stabilizing composition for chlorine-containing polymers | ARKEMA (FR) | 2006-10-18 | — | — | CN | disclosed |
| CN-1834090-A | Benzimidazole compounds, its prepn. and uses | SHANGHAI INST OF MEDICINES C A (CN) | 2006-09-20 | — | — | CN | disclosed |
| CN-1346344-A | Substituted 2-aminobenzamide caspase ihibitors and the use thereof | CYTOVIA INC (US) | 2002-04-24 | — | — | CN | disclosed |