Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943392 | 0.91 | ITGB1 (0.38) | CASRBACE1MKNK1ALOX5PDK1 | |
| SCHEMBL3945373 | 0.91 | CASR (0.37) | CASRBACE1MKNK1ALOX5PDK1 | |
| SCHEMBL3950139 | 0.91 | CASR (0.37) | CASRMEN1KMT2AITGB1ITGA4 | |
| SCHEMBL3951648 | 0.91 | TSPO (0.37) | CASROPRK1BACE1MKNK1ALOX5 | |
| SCHEMBL3942436 | 0.91 | CASR (0.42) | CASROPRK1MKNK1PDK1 | |
| SCHEMBL3947316 | 0.90 | CASR (0.41) | CASRBACE1MKNK1ALOX5PDK1 | |
| SCHEMBL3946983 | 0.82 | CASR (0.43) | CASRPDK1MEN1KMT2AITGB1 | |
| SCHEMBL3942446 | 0.82 | CASR (0.41) | CASROPRK1BACE1ALOX5PDK1 | |
| SCHEMBL3951654 | 0.81 | CASR (0.41) | CASRBACE1MEN1KMT2A | |
| SCHEMBL3945147 | 0.81 | TSPO (0.37) | CASRPDK1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |