Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942067 | 0.90 | HTT (0.46) | HTTKMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3943049 | 0.90 | HTT (0.48) | HTTKMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3942111 | 0.89 | HTT (0.46) | HTTKMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3950411 | 0.89 | HTT (0.36) | HTTKMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3950166 | 0.87 | ROCK2 (0.37) | HTTROCK2GAA | |
| SCHEMBL13942349 | 0.87 | HTT (0.54) | HTTKMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL13942061 | 0.86 | HTT (0.52) | HTTKMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3951550 | 0.84 | HTT (0.51) | HTTKMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3945166 | 0.84 | HTT (0.57) | HTTKMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3951093 | 0.84 | HTT (0.55) | HTTKMT2AKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |