Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950517 | 0.89 | HTT (0.37) | HTTSMN1; SMN2ALDH1A1KMT2AKDM4E | |
| SCHEMBL3945208 | 0.89 | HTT (0.44) | HTTSMN1; SMN2ALDH1A1KMT2AKDM4E | |
| SCHEMBL3951301 | 0.85 | HTT (0.46) | HTTSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL3944413 | 0.84 | SMN1; SMN2 (0.46) | HTTSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL3942783 | 0.84 | HTT (0.51) | HTTSMN1; SMN2ALDH1A1KMT2AKDM4E | |
| SCHEMBL3945317 | 0.83 | SMN1; SMN2 (0.44) | HTTSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL3948146 | 0.82 | SMN1; SMN2 (0.52) | HTTSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL3951125 | 0.81 | SMN1; SMN2 (0.39) | HTTSMN1; SMN2ALDH1A1KMT2AKDM4E | |
| SCHEMBL3951519 | 0.81 | SMN1; SMN2 (0.44) | HTTSMN1; SMN2ALDH1A1KMT2ATSHR | |
| SCHEMBL3946321 | 0.81 | LMNA (0.40) | HTTSMN1; SMN2ALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |