Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3745741 | 0.89 | SCN9A (0.55) | KMT2ASCN9AKCNH2SCN5AKCNA5 | |
| SCHEMBL3946919 | 0.88 | ALDH1A1 (0.51) | ALDH1A1LMNASMN1; SMN2KMT2AMAPT | |
| SCHEMBL3942840 | 0.86 | ALDH1A1 (0.69) | ALDH1A1LMNASMN1; SMN2KMT2ASCN9A | |
| SCHEMBL3750116 | 0.86 | SCN9A (0.52) | KMT2ASCN9AKCNH2SCN5AKCNA5 | |
| SCHEMBL3745536 | 0.83 | SCN9A (0.46) | KMT2ASCN9AKCNH2SCN5AKCNA5 | |
| SCHEMBL3759970 | 0.80 | SCN9A (0.65) | SCN9AKCNH2SCN5AKCNA5 | |
| SCHEMBL3753733 | 0.80 | ALDH1A1 (0.62) | ALDH1A1LMNASMN1; SMN2KMT2ASCN9A | |
| SCHEMBL3758084 | 0.80 | ALDH1A1 (0.67) | ALDH1A1LMNASMN1; SMN2KMT2ASCN9A | |
| SCHEMBL3760109 | 0.80 | KCNA5 (0.45) | SCN9AKCNH2SCN5AKCNA5 | |
| SCHEMBL3761072 | 0.79 | ALDH1A1 (0.64) | ALDH1A1LMNASMN1; SMN2KCNH2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | claimed |