Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.35 |
| ▸ | CASP1 | P29466 | 6/20 | 0.35 |
| ▸ | SAE1 | Q9UBE0 | 6/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NSD2 | O96028 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | CASP6 | P55212 | 2/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3935452 | 0.85 | TBXAS1 (0.36) | HSD17B10CASP1SAE1UBA2MEN1 | |
| SCHEMBL3937243 | 0.85 | ALDH1A1 (0.41) | HSD17B10MEN1KMT2AKDM4ENPSR1 | |
| SCHEMBL3943576 | 0.85 | ALDH1A1 (0.37) | KMT2AKDM4ENPSR1POLBLMNA | |
| SCHEMBL7125506 | 0.82 | ALDH1A1 (0.39) | HSD17B10MEN1KMT2AKDM4ENPSR1 | |
| SCHEMBL3936916 | 0.82 | ALDH1A1 (0.34) | HSD17B10MEN1KMT2AKDM4ENPSR1 | |
| SCHEMBL3936582 | 0.81 | ALDH1A1 (0.35) | HSD17B10MEN1KMT2AKDM4ELMNA | |
| Propionic Acid SCHEMBL3938090 | 0.81 | TP53 (0.38) | KDM4EPOLBTP53MAPK1ADORA2A | |
| SCHEMBL4132211 | 0.80 | ALDH1A1 (0.34) | HSD17B10CASP1SAE1UBA2MEN1 | |
| SCHEMBL3936795 | 0.80 | ALDH1A1 (0.36) | HSD17B10MEN1KMT2AKDM4EALOX15 | |
| SCHEMBL3934038 | 0.79 | POLB (0.41) | POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528140-B2 | Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors | TEIJIN LIMITED (JP) | 2009-05-05 | — | — | US | disclosed |
| US-7528140-B2 | Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors | TEIJIN LIMITED (JP) | 2009-05-05 | — | — | US | disclosed |
| US-20050277773-A1 | Pyrrolopyrimidine derivatives | TEIJIN LIMITED (JP) | 2005-12-15 | — | — | US | disclosed |
| EP-1477489-A1 | PYRROLOPYRIMIDINE DERIVATIVES | TEIJIN LIMITED (JP) | 2004-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277773-A1 | Pyrrolopyrimidine derivatives | GSK3B, GSK3A, GSKIP | HSD17B10 1357/4885CASP1 1659/4885SAE1 2822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.