Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.46 |
| ▸ | PGR | P06401 | 7/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27754237 | 0.86 | NR3C1 (0.45) | LOXL2NR3C1PGRNR3C2CYP2D6 | |
| SCHEMBL3653908 | 0.86 | NR3C1 (0.55) | LOXL2NR3C1PGRNR3C2 | |
| SCHEMBL27754238 | 0.83 | LOXL2 (0.44) | LOXL2NR3C1PGRNR3C2CYP2D6 | |
| SCHEMBL5821510 | 0.82 | LOXL2 (0.43) | LOXL2NR3C1PGRNR3C2CYP2D6 | |
| SCHEMBL28246983 | 0.81 | LOXL2 (0.55) | LOXL2NR3C1PGRNR3C2CYP2D6 | |
| SCHEMBL5860946 | 0.78 | CYP2D6 (0.47) | LOXL2NR3C1PGRNR3C2CYP2D6 | |
| SCHEMBL9734545 | 0.77 | LOXL2 (0.58) | LOXL2NR3C1PGRNR3C2MTNR1A | |
| SCHEMBL10945651 | 0.74 | LOXL2 (0.59) | LOXL2NR3C1PGRNR3C2MTNR1A | |
| SCHEMBL31280332 | 0.74 | LOXL2 (0.55) | LOXL2NR3C1PGRNR3C2MTNR1A | |
| SCHEMBL9027554 | 0.74 | LOXL2 (0.58) | LOXL2MTNR1AMTNR1BCASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051710-A2 | COMPOSITIONS AND METHODS FOR TREATING, REDUCING, AMELIORATING, OR ALLEVIATING POSTERIOR-SEGMENT OPHTHALMIC DISEASES | Bausch & Lomb Incorporated (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008021729-A2 | COMPOSITIONS AND METHODS FOR TREATING, REDUCING, AMELIORATING, OR ALLEVIATING POSTERIOR-SEGMENT OPHTHALMIC DISEASES | BAUSCH & LOMB INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |