Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.76 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.76 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.51 |
| ▸ | CDK4 | P11802 | 3/20 | 0.51 |
| ▸ | CCND1 | P24385 | 3/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | PIM1 | P11309 | 3/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | S100A4 | P26447 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 2/20 | 0.49 |
| ▸ | PRKACG | P22612 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20624158 | 0.93 | SIRT2 (0.63) | SIRT2SIRT1CAMK2DRPS6KB1HTR1A | |
| SCHEMBL3945882 | 0.87 | SIRT2 (1.00) | SIRT2SIRT1CAMK2DRPS6KB1CCNE2 | |
| SCHEMBL30958473 | 0.87 | SIRT2 (1.00) | SIRT2SIRT1CAMK2DRPS6KB1CCNE2 | |
| SCHEMBL20624204 | 0.85 | SIRT2 (0.63) | SIRT2SIRT1CAMK2DRPS6KB1HTR1A | |
| SCHEMBL5343477 | 0.83 | SIRT2 (0.80) | SIRT2SIRT1CAMK2DRPS6KB1CCNE2 | |
| SCHEMBL7822950 | 0.82 | PRKCB (0.74) | SIRT2CAMK2DCCNE2CDK4CCND1 | |
| SCHEMBL3662574 | 0.81 | S100A4 (0.55) | SIRT2CAMK2DHTR1AHTR7HTR6 | |
| SCHEMBL7825953 | 0.80 | SIRT2 (0.72) | SIRT2SIRT1CAMK2DRPS6KB1CCNE2 | |
| SCHEMBL18392166 | 0.79 | S100A4 (0.54) | SIRT2SIRT1CAMK2DCCNE2CDK4 | |
| SCHEMBL28673726 | 0.79 | CAMK2D (0.53) | SIRT2SIRT1CAMK2DRPS6KB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |
| WO-2003051887-A1 | N-CARBACYCLE MONOSUBSTITUTED INDOLOCARBAZOLES AS PROTEIN KINASE INHIBITORS | NAD AG (DE) | 2003-06-26 | — | — | WO | disclosed |