SCHEMBL3946610

SCHEMBL3946610

CCC1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@H]3CC[C@@]21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SHBG P04278 7/20 0.74
NR3C1 P04150 4/20 0.74
PGR P06401 3/20 0.74
ALDH1A1 P00352 3/20 0.74
ADRA1A P35348 1/20 0.74
HTR2B P41595 1/20 0.74
LMNA P02545 7/20 0.70
SMN1; SMN2 Q16637 5/20 0.70
TSHR P16473 4/20 0.70
CYP2C19 P33261 3/20 0.70
AR P10275 3/20 0.70
MEN1 O00255 2/20 0.70
KMT2A Q03164 2/20 0.70
HIF1A Q16665 2/20 0.70
THRB P10828 1/20 0.70
ESR1 P03372 1/20 0.70
SERPINA6 P08185 6/20 0.68
BLM P54132 4/20 0.68
MAPT P10636 2/20 0.68
ADORA3 P0DMS8 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL571189 1.00 SHBG (0.74) SHBGNR3C1PGRALDH1A1ADRA1A
SCHEMBL634733 1.00 SHBG (0.74) SHBGNR3C1PGRALDH1A1ADRA1A
Topterone SCHEMBL140769 0.91 SHBG (0.71) SHBGNR3C1PGRALDH1A1ADRA1A
Topterone SCHEMBL11730925 0.91 SHBG (0.71) SHBGNR3C1PGRALDH1A1ADRA1A
Topterone SCHEMBL8846971 0.91 SHBG (0.71) SHBGNR3C1PGRALDH1A1ADRA1A
Topterone SCHEMBL3844149 0.91 SHBG (0.71) SHBGNR3C1PGRALDH1A1ADRA1A
SCHEMBL11728942 0.89 SHBG (0.68) SHBGNR3C1PGRALDH1A1ADRA1A
SCHEMBL10393805 0.89 SHBG (0.68) SHBGNR3C1PGRALDH1A1ADRA1A
SCHEMBL8236612 0.89 SHBG (0.68) SHBGNR3C1PGRALDH1A1ADRA1A
SCHEMBL29437217 0.88 SHBG (0.71) SHBGNR3C1PGRALDH1A1ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009012955-A2 PROCESS FOR THE PREPARATION OF DROSPIRENONE NEWCHEM S.P.A. (IT) 2009-01-29 WO disclosed
US-4859659-A ACNE TREATMENT SCHERING AKTIENGESELLSCHAFT (DE) 1989-08-22 US disclosed
US-4160027-A OXYTOCICS, 4A,5A-EPOXY-2A-CYANO-3-OXOSTEROIDES, STEROIDO(2,3-O)ISOOXAZOLES STERLING DRUG INC. (US) 1979-07-03 US disclosed
US-4039669-A DERMATOLOGICAL CONDITIONS, ACNE, STEROIDS STERLING DRUG INC. (US) 1977-08-02 US disclosed