Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17626132 | 0.77 | MAPT (0.43) | HPGDGAAMAPTTDP1KDM4E | |
| SCHEMBL2750716 | 0.76 | GAA (0.37) | HTR1AHTR3AL3MBTL1HPGDTSHR | |
| SCHEMBL1435851 | 0.75 | CYP19A1 (0.47) | HPGDGAAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL7227702 | 0.73 | IDO1 (0.42) | HPGDTSHRMAPK1GAAMAPT | |
| SCHEMBL17626197 | 0.73 | PTPRC (0.43) | HPGDMAPTTDP1KDM4E | |
| SCHEMBL8737305 | 0.71 | HTR1A (0.55) | HTR1AHTR3AL3MBTL1HPGDTSHR | |
| SCHEMBL31666386 | 0.69 | HTR1A (0.50) | HTR1AHTR3AL3MBTL1GAAMAPT | |
| SCHEMBL4950654 | 0.69 | HTR1A (0.50) | HTR1AHTR3AL3MBTL1GAAMAPT | |
| SCHEMBL3605029 | 0.69 | ATP4A (0.45) | MAPK1MAPTTDP1KDM4EKMT2A | |
| SCHEMBL6175479 | 0.68 | HDAC1 (0.35) | MAPTNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010508-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120096-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |