SCHEMBL7779128

SCHEMBL7779128

O=C(Nc1ccc2oc(-c3cccc(Cl)c3Cl)nc2c1)c1ccccc1Br

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 13/20 0.75
TP53 P04637 10/20 0.72
SMN1; SMN2 Q16637 5/20 0.67
PPARG P37231 1/20 0.63
RXFP1 Q9HBX9 2/20 0.62
NPC1 O15118 5/20 0.60
RAB9A P51151 5/20 0.60
HSD17B10 Q99714 4/20 0.60
ALDH1A1 P00352 3/20 0.60
MEN1 O00255 1/20 0.60
KMT2A Q03164 1/20 0.60
NPSR1 Q6W5P4 1/20 0.60
THRB P10828 2/20 0.60
HPGD P15428 3/20 0.60
NFKB1 P19838 2/20 0.60
NFKB2 Q00653 2/20 0.60
RELA Q04206 2/20 0.60
KDM4E B2RXH2 2/20 0.60
PTGS2 P35354 1/20 0.59
LMNA P02545 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2247720 0.93 MAPT (0.78) MAPTTP53SMN1; SMN2PPARGRXFP1
SCHEMBL27188317 0.80 PPARG (0.79) MAPTTP53SMN1; SMN2PPARGTHRB
SCHEMBL23009047 0.80 MAPT (1.00) MAPTTP53SMN1; SMN2PPARGRXFP1
SCHEMBL2240335 0.79 NPC1 (0.70) MAPTTP53SMN1; SMN2NPC1RAB9A
SCHEMBL3947178 0.78 TP53 (0.64) MAPTTP53SMN1; SMN2RXFP1NPC1
SCHEMBL3457640 0.78 MAPT (0.86) MAPTTP53SMN1; SMN2PPARGRXFP1
SCHEMBL4034648 0.78 MAPT (0.63) MAPTTP53SMN1; SMN2NPC1RAB9A
SCHEMBL4034654 0.78 MAPT (0.63) MAPTTP53SMN1; SMN2NPC1RAB9A
SCHEMBL27188292 0.78 PPARG (1.00) MAPTTP53SMN1; SMN2PPARGNPC1
SCHEMBL2242957 0.77 TP53 (0.62) MAPTTP53SMN1; SMN2RXFP1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10472495-B2 Colored resin composition exhibiting pleochroism, and molded plastics manufactured using same LOTTE ADVANCED MATERIALS CO., LTD. (KR) 2019-11-12 US disclosed
US-20180127566-A1 Colored Resin Composition Exhibiting Pleochroism, and Molded Plastics Manufactured Using Same LOTTE ADVANCED MAT CO LTD (KR) 2018-05-10 US disclosed
US-9868849-B2 Colored resin composition exhibiting pleochroism, and molded plastics manufactured using same LOTTE ADVANCED MATERIALS CO., LTD. (KR) 2018-01-16 US disclosed
EP-2810974-B1 COLORED RESIN COMPOSITION EXHIBITING PLEOCHROISM, AND MOLDED PLASTICS MANUFACTURED USING SAME LOTTE ADVANCED MAT CO LTD (KR) 2017-10-04 EP disclosed
US-20140374676-A1 Colored Resin Composition Exhibiting Pleochroism, and Molded Plastics Manufactured Using Same SAMSUNG SDI CO., LTD. (KR) 2014-12-25 US disclosed
EP-2810974-A1 COLORED RESIN COMPOSITION EXHIBITING PLEOCHROISM, AND MOLDED PLASTICS MANUFACTURED USING SAME Samsung SDI Co., Ltd. (KR) 2014-12-10 EP disclosed
CN-104105741-A POLYCHROMATIC RESIN COMPOSITION AND MOLDED ARTICLES EMPLOYING SAME SAMSUNG SDI CORP 2014-10-15 CN disclosed
EP-0683200-B1 Stabilizer composition GEN ELECTRIC (US) 2001-09-26 EP disclosed
US-5608027-A HEAT STABLE OR COLORFASTNESS GENERAL ELECTRIC COMPANY (US) 1997-03-04 US disclosed
CN-1113500-A A compolex stabilizer composition to improve the melt stability and color stability of polycarbonates GEN ELECTRIC (US) 1995-12-20 CN disclosed