Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1209794 | 0.90 | PTPN5 (0.45) | ALDH1A1POLBPTPN5TGFBR1KDM4E | |
| SCHEMBL1210565 | 0.89 | ALDH1A1 (0.41) | ALDH1A1POLBPTPN5TGFBR1KDM4E | |
| SCHEMBL1207619 | 0.89 | ALDH1A1 (0.41) | ALDH1A1POLBPTPN5TGFBR1KDM4E | |
| SCHEMBL12882703 | 0.89 | ALDH1A1 (0.41) | ALDH1A1POLBPTPN5TGFBR1KDM4E | |
| SCHEMBL3955346 | 0.89 | PTPN5 (0.40) | ALDH1A1POLBPTPN5TGFBR1KDM4E | |
| SCHEMBL1209628 | 0.88 | ALDH1A1 (0.48) | ALDH1A1POLBPTPN5TGFBR1KDM4E | |
| SCHEMBL1207698 | 0.88 | NOD1 (0.47) | ALDH1A1POLBPTPN5TGFBR1KDM4E | |
| SCHEMBL1207805 | 0.87 | PTPN5 (0.40) | ALDH1A1POLBPTPN5TGFBR1KDM4E | |
| SCHEMBL1210808 | 0.86 | ALDH1A1 (0.41) | ALDH1A1POLBPTPN5TGFBR1KDM4E | |
| SCHEMBL1209502 | 0.86 | ALDH1A1 (0.54) | ALDH1A1POLBPTPN5TGFBR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051974-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008020045-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2008-02-21 | — | — | WO | disclosed |