Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.43 |
| ▸ | LOX | P28300 | 2/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | KRAS | P01116 | 2/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017517 | 0.85 | LOXL2 (0.41) | RECQLLOXL2LOXKCNQ2LOXL3 | |
| SCHEMBL29988849 | 0.80 | LOXL2 (0.67) | RECQLLOXL2LOXKCNQ2 | |
| SCHEMBL9057494 | 0.80 | LOXL2 (0.67) | RECQLLOXL2LOXKCNQ2 | |
| SCHEMBL13718960 | 0.80 | RECQL (0.52) | RECQLLOXL2LOXPLAUPRKCI | |
| SCHEMBL2323334 | 0.78 | RECQL (0.50) | RECQLLOXL2LOXPLAUPRKCI | |
| SCHEMBL29504608 | 0.78 | RECQL (0.50) | RECQLLOXL2LOXPLAUPRKCI | |
| SCHEMBL8764955 | 0.72 | SMARCA2 (0.33) | LOXL2CYP3A4LMNASMN1; SMN2CA12 | |
| SCHEMBL451390 | 0.72 | — | — | |
| SCHEMBL13541414 | 0.72 | RECQL (0.61) | RECQLLOXL2LOXPLAUKRAS | |
| SCHEMBL29393772 | 0.72 | RECQL (0.61) | RECQLLOXL2PLAUKRASPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572905-B1 | Apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression | MYRIAD GENETICS, INC. (US) | 2009-08-11 | — | — | US | disclosed |