Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | PNMT | P11086 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16957160 | 0.82 | TRPV1 (0.39) | CHRM5TRPV1PNMTIDO1KMT2A | |
| SCHEMBL8978656 | 0.80 | KMT2A (0.38) | CHRM5TRPV1KMT2AP2RX7MEN1 | |
| SCHEMBL7334130 | 0.79 | KMT2A (0.35) | PNMTIDO1KMT2AMEN1MAPT | |
| SCHEMBL28767032 | 0.79 | TRPV1 (0.37) | CHRM5TRPV1PNMTIDO1KMT2A | |
| SCHEMBL30423276 | 0.76 | CASR (0.38) | PNMTIDO1KMT2AP2RX7MEN1 | |
| SCHEMBL29937335 | 0.76 | GRIA1 (0.33) | CHRM5TRPV1KMT2AP2RX7MEN1 | |
| SCHEMBL10873536 | 0.76 | GRIA1 (0.33) | CHRM5TRPV1KMT2AP2RX7MEN1 | |
| SCHEMBL4904132 | 0.76 | CASR (0.38) | PNMTIDO1KMT2AP2RX7MEN1 | |
| SCHEMBL28193021 | 0.75 | P2RX7 (0.40) | P2RX7GRIN2BGRIA1CACNG8 | |
| SCHEMBL20863155 | 0.73 | TAAR1 (0.36) | PNMTIDO1P2RX7TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049517-A1 | AMINO-PIPERIDINE DERIVATIVES AS CETP INHIBITORS | Novartis AG (CH) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008009435-A1 | AMINO-PIPERIDINE DERIVATIVES AS CETP INHIBITORS | NOVARTIS AG (CH) | 2008-01-24 | — | — | WO | disclosed |