SCHEMBL394844

SCHEMBL394844

COc1cc(OC)cc(C(=O)Cc2ccc(OC(C)C)cc2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.58
NPC1 O15118 3/20 0.50
LMNA P02545 2/20 0.50
HTT P42858 2/20 0.50
ALDH1A1 P00352 2/20 0.47
KMT2A Q03164 3/20 0.46
RAB9A P51151 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
MEN1 O00255 1/20 0.46
CYP3A4 P08684 1/20 0.46
HPGD P15428 1/20 0.46
ATM Q13315 1/20 0.46
PARP10 Q53GL7 1/20 0.45
USP2 O75604 1/20 0.44
TP53 P04637 1/20 0.44
GAA P10253 1/20 0.44
MAPK1 P28482 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
HSP90AA1 P07900 1/20 0.44
CNR2 P34972 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3099717 0.88 POLB (0.61) POLBNPC1LMNAHTTALDH1A1
SCHEMBL392612 0.88 NPC1 (0.62) POLBNPC1LMNAHTTALDH1A1
SCHEMBL4422487 0.79 NPC1 (0.56) POLBNPC1LMNAHTTALDH1A1
SCHEMBL21780777 0.77 POLB (0.55) POLBNPC1LMNAHTTALDH1A1
SCHEMBL7641019 0.77 NPC1 (0.58) POLBNPC1LMNAHTTALDH1A1
SCHEMBL393881 0.76 LMNA (0.78) POLBNPC1LMNAHTTALDH1A1
SCHEMBL457954 0.76 NPC1 (0.73) NPC1LMNAHTTALDH1A1KMT2A
SCHEMBL18326335 0.75 MEN1 (0.54) POLBNPC1LMNAHTTALDH1A1
SCHEMBL392767 0.74 POLB (0.69) POLBNPC1LMNAALDH1A1KMT2A
SCHEMBL5524526 0.74 POLB (0.55) POLBHTTALDH1A1KMT2APARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2202215-B1 Novel process for the synthesis of (E)-Stilbene derivatives which makes it possible to obtain resveratrol and piceatannol CLARIANT SPECIALTY FINE CHEM F (FR) 2013-10-02 EP disclosed
EP-2049459-B1 NOVEL PROCESS FOR THE SYNTHESIS OF (E)-STILBENE DERIVATIVES WHICH MAKES IT POSSIBLE TO OBTAIN RESVERATROL AND PICEATANNOL CLARIANT SPECIALTY FINE CHEM F (FR) 2013-10-02 EP disclosed
US-8101804-B2 Process for the synthesis of (E)-stilbene derivatives which makes it possible to obtain resveratrol and piceatannol CLARIANT SPECIALTY FINE CHEMICALS (FRANCE) (FR) 2012-01-24 US disclosed
EP-2202215-A2 Novel process for the synthesis of (E)-Stilbene derivatives which makes it possible to obtain resveratrol and piceatannol Clariant Specialty Fine Chemicals (France) (FR) 2010-06-30 EP disclosed
US-20100004483-A1 Novel Process For The Synthesis Of (E)-Stilbene Derivatives Which Makes It Possible To Obtain Resveratrol And Piceatannol CLARIANT SPECIALTY FINE CHEMICALS (FRANCE) (FR) 2010-01-07 US disclosed
EP-2049459-A1 NOVEL PROCESS FOR THE SYNTHESIS OF (E)-STILBENE DERIVATIVES WHICH MAKES IT POSSIBLE TO OBTAIN RESVERATROL AND PICEATANNOL Clariant Specialty Fine Chemicals (France) (FR) 2009-04-22 EP disclosed
WO-2008012321-A1 NOVEL PROCESS FOR THE SYNTHESIS OF (E)-STILBENE DERIVATIVES WHICH MAKES IT POSSIBLE TO OBTAIN RESVERATROL AND PICEATANNOL CLARIANT SPECIALTY FINE CHEMICALS (FRANCE) (FR) 2008-01-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100004483-A1 Novel Process For The Synthesis Of (E)-Stilbene Derivatives Which Makes It Possible To Obtain Resveratrol And Piceatannol SQLE, SUCLA2, SORD POLB 2635/4885NPC1 2050/4885LMNA 2065/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.