Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CASP6 | P55212 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582939 | 0.79 | MAPT (0.46) | MAPTKDM4ETDP1ALDH1A1CASP6 | |
| SCHEMBL3583091 | 0.67 | MAPT (0.45) | MAPTKDM4ETDP1ALDH1A1CASP6 | |
| SCHEMBL3948484 | 0.66 | — | — | |
| SCHEMBL3580119 | 0.65 | KDM4E (0.41) | MAPTKDM4ETDP1ALDH1A1CASP6 | |
| SCHEMBL29652066 | 0.61 | GPR35 (0.54) | ALDH1A1SMN1; SMN2CTSBL3MBTL1THRB | |
| SCHEMBL7435964 | 0.61 | S100A4 (0.40) | MAPTKDM4EALDH1A1CASP6SMN1; SMN2 | |
| SCHEMBL27190038 | 0.61 | MAPT (0.59) | MAPTKDM4ETDP1ALDH1A1CASP6 | |
| SCHEMBL30541541 | 0.61 | FEN1 (0.50) | MAPTKDM4ETDP1ALDH1A1CASP6 | |
| SCHEMBL11371962 | 0.61 | FEN1 (0.50) | MAPTKDM4ETDP1ALDH1A1CASP6 | |
| SCHEMBL11365341 | 0.60 | FEN1 (0.49) | MAPTKDM4ETDP1ALDH1A1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027091-A1 | NEW PHARMACEUTICAL COMPOUNDS | BIAL - Portela & Ca., S.A. (PT) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007117165-A1 | NEW PHARMACEUTICAL COMPOUNDS | BIAL - PORTELA & CA, S.A. (PT) | 2007-10-18 | — | — | WO | disclosed |