Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 11/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21286395 | 1.00 | ABCB1 (0.38) | ABCB1SRCIDO1PARP1BRD4 | |
| SCHEMBL29985450 | 1.00 | ABCB1 (0.38) | ABCB1SRCIDO1PARP1BRD4 | |
| SCHEMBL21272035 | 0.89 | KDM4E (0.36) | TP53MEN1KMT2A | |
| SCHEMBL4294393 | 0.89 | KDM4E (0.36) | TP53MEN1KMT2A | |
| SCHEMBL21271883 | 0.89 | KDM4E (0.36) | TP53MEN1KMT2A | |
| SCHEMBL1526218 | 0.86 | ABCB1 (0.37) | ABCB1SRCIDO1PARP1UCHL1 | |
| SCHEMBL1526220 | 0.86 | ABCB1 (0.37) | ABCB1SRCIDO1PARP1UCHL1 | |
| SCHEMBL8575658 | 0.85 | ABCB1 (0.38) | ABCB1SRCIDO1PARP1BRD4 | |
| SCHEMBL8098384 | 0.85 | ABCB1 (0.38) | ABCB1SRCIDO1PARP1UCHL1 | |
| SCHEMBL263737 | 0.83 | JAK2 (0.38) | SRCIDO1BRD4TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026197-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-02-26 | — | — | WO | disclosed |