Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2575409 | 0.75 | P2RX7 (0.39) | POLBESR1MEN1KMT2AMAPT | |
| SCHEMBL2575412 | 0.75 | P2RX7 (0.39) | POLBESR1MEN1KMT2AMAPT | |
| SCHEMBL12570331 | 0.74 | LMNA (0.34) | POLBMAPT | |
| SCHEMBL10211148 | 0.69 | POLB (0.35) | POLBMAPT | |
| SCHEMBL3948661 | 0.67 | POLB (0.47) | POLBESR1MEN1KMT2AMAPT | |
| SCHEMBL5835997 | 0.67 | ITGB1 (0.43) | POLBMAPTRIPK1 | |
| SCHEMBL2580342 | 0.66 | MAPK1 (0.41) | POLB | |
| SCHEMBL2580343 | 0.66 | MAPK1 (0.41) | POLB | |
| SCHEMBL23636347 | 0.64 | ACE (0.44) | POLBMEN1KMT2AMAPT | |
| SCHEMBL19862758 | 0.64 | ACE (0.44) | POLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074518-A1 | COMBINATIONS OF PROLINAMIDE P2X7 MODULATORS WITH FURTHER THERAPEUTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2009-06-18 | — | — | WO | disclosed |
| EP-2049478-A1 | SUBSTITUTED N-PHENYLMETHYL -5-OXO-PROLINE-2-AMIDES AS P2X7-RECEPTOR ANTAGONISTS AND THEIR METHODS OF USE | Glaxo Group Limited (GB) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008003697-A1 | SUBSTITUTED N-PHENYLMETHYL -5-OXO-PROLINE-2-AMIDES AS P2X7-RECEPTOR ANTAGONISTS AND THEIR METHODS OF USE | GLAXO GROUP LIMITED (GB) | 2008-01-10 | — | — | WO | disclosed |