Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.43 |
| ▸ | HINT1 | P49773 | 1/20 | 0.42 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.40 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3948848 | 1.00 | POLB (0.46) | POLBUPP1HINT1RNASE1NT5E | |
| SCHEMBL14614375 | 1.00 | POLB (0.46) | POLBUPP1HINT1RNASE1NT5E | |
| SCHEMBL13664951 | 1.00 | POLB (0.46) | POLBUPP1HINT1RNASE1NT5E | |
| SCHEMBL3956852 | 0.92 | LMNA (0.49) | POLBUPP1RNASE1NT5ELMNA | |
| SCHEMBL3956850 | 0.92 | LMNA (0.49) | POLBUPP1RNASE1NT5ELMNA | |
| SCHEMBL15031043 | 0.92 | LMNA (0.49) | POLBUPP1RNASE1NT5ELMNA | |
| SCHEMBL13664950 | 0.92 | LMNA (0.49) | POLBUPP1RNASE1NT5ELMNA | |
| SCHEMBL7915780 | 0.92 | UPP1 (0.44) | UPP1HINT1RNASE1NT5ELMNA | |
| SCHEMBL7915783 | 0.92 | UPP1 (0.44) | UPP1HINT1RNASE1NT5ELMNA | |
| SCHEMBL13743349 | 0.91 | POLB (0.46) | POLBUPP1RNASE1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466275-B2 | Method for the preparation of 2-halo-2′-deoxyadenosine compounds from 2′-deoxyguanosine | BRIGHAM YOUNG UNIVERSITY (US) | 2013-06-18 | — | — | US | disclosed |
| EP-1556400-B1 | METHOD FOR THE PREPARATION OF 2-HALO-2 -DEOXYADENOSINE COMPOUNDS FROM 2 -DEOXYGUANOSINE | UNIV BRIGHAM YOUNG (US) | 2013-05-01 | — | — | EP | disclosed |
| US-20090270604-A1 | METHOD FOR THE PREPARATION OF 2-HALO-2'-DEOXYADENOSINE COMPOUNDS FROM 2'-DEOXYGUANOSINE | BRIGHAM YOUNG UNIVERSITY | 2009-10-29 | — | — | US | disclosed |
| US-7572909-B2 | Method for the preparation of 2-halo-2′-deoxyadenosine compounds from 2′-deoxyguanosine | BRIGHAM YOUNG UNIVERSITY (US) | 2009-08-11 | — | — | US | disclosed |
| US-20070032645-A1 | Method for the preparation of 2-halo-2'-deoxyadenosine compounds for 2'-deoxyguanosine | BRIGHAM YOUNG UNIVERSITY (US) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032645-A1 | Method for the preparation of 2-halo-2'-deoxyadenosine compounds for 2'-deoxyguanosine | DCTD, CDA, UNG | POLB 415/4885UPP1 212/4885HINT1 657/4885 |
| US-20090270604-A1 | METHOD FOR THE PREPARATION OF 2-HALO-2'-DEOXYADENOSINE COMPOUNDS FROM 2'-DEOXYGUANOSINE | DCTD, CDA, UNG | POLB 399/4885UPP1 215/4885HINT1 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.