Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UPP1 | Q16831 | 1/20 | 0.44 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 2/20 | 0.40 |
| ▸ | PNP | P00491 | 2/20 | 0.39 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HINT1 | P49773 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7915780 | 1.00 | UPP1 (0.44) | UPP1P2RY1LMNATP53ALDH1A1 | |
| SCHEMBL6559404 | 0.92 | LMNA (0.49) | UPP1P2RY1LMNATP53ALDH1A1 | |
| SCHEMBL9393705 | 0.92 | LMNA (0.49) | UPP1P2RY1LMNATP53ALDH1A1 | |
| SCHEMBL6559406 | 0.92 | LMNA (0.49) | UPP1P2RY1LMNATP53ALDH1A1 | |
| SCHEMBL7200818 | 0.92 | LMNA (0.49) | UPP1P2RY1LMNATP53ALDH1A1 | |
| SCHEMBL3948851 | 0.92 | POLB (0.46) | UPP1P2RY1LMNATP53ALDH1A1 | |
| SCHEMBL14614375 | 0.92 | POLB (0.46) | UPP1P2RY1LMNATP53ALDH1A1 | |
| SCHEMBL3948848 | 0.92 | POLB (0.46) | UPP1P2RY1LMNATP53ALDH1A1 | |
| SCHEMBL13664951 | 0.92 | POLB (0.46) | UPP1P2RY1LMNATP53ALDH1A1 | |
| SCHEMBL10624665 | 0.91 | UPP1 (0.43) | UPP1P2RY1LMNATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232463-B1 | CROSSLINKING OLIGONUCLEOTIDES CONTAINING PURINE ANALOGS HAVING REACTIVE SITES ON THE NUCLEOBASE AND ON A SUGAR MOIETY; ANTISENSE AGENTS | ISIS PHARMACEUTICALS, INC. | 2001-05-15 | — | — | US | disclosed |
| US-5811534-A | PURINE-BASED COMPOUNDS FOR INCLUSION INTO OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1998-09-22 | — | — | US | disclosed |
| US-5681941-A | GENETIC ENGINEERING; CROSSLINKING OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |