Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954098 | 0.92 | ALDH1A1 (0.41) | SMN1; SMN2TP53ALDH1A1USP2HPGD | |
| SCHEMBL3955889 | 0.92 | ACE2 (0.38) | SMN1; SMN2TP53ALDH1A1USP2HPGD | |
| SCHEMBL3950649 | 0.84 | CHRM1 (0.40) | ALDH1A1 | |
| SCHEMBL1306925 | 0.83 | HRH3 (0.46) | SMN1; SMN2TP53LMNAMAPTMAPK1 | |
| SCHEMBL3927123 | 0.82 | PAOX (0.44) | SMN1; SMN2TP53USP2KDM4EKMT2A | |
| SCHEMBL1307275 | 0.82 | HRH3 (0.50) | SMN1; SMN2ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL3948571 | 0.81 | CHRM4 (0.38) | ALDH1A1 | |
| SCHEMBL3954996 | 0.80 | USP2 (0.41) | SMN1; SMN2TP53ALDH1A1USP2KDM4E | |
| SCHEMBL3937634 | 0.80 | SLC2A1 (0.40) | SMN1; SMN2TP53ALDH1A1USP2GAA | |
| SCHEMBL3949628 | 0.79 | ALDH1A1 (0.43) | TP53ALDH1A1HPGDDUSP3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |