Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949503 | 0.92 | SMN1; SMN2 (0.40) | ACE2SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL3949628 | 0.88 | ALDH1A1 (0.43) | ACE2TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL3954098 | 0.84 | ALDH1A1 (0.41) | SMN1; SMN2TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL3948571 | 0.81 | CHRM4 (0.38) | ALDH1A1 | |
| SCHEMBL3950649 | 0.80 | CHRM1 (0.40) | ALDH1A1 | |
| SCHEMBL1307630 | 0.79 | CARM1 (0.50) | ACE2ALDH1A1POLBKDM4EMAPT | |
| SCHEMBL5748703 | 0.79 | — | — | |
| SCHEMBL3952866 | 0.78 | CHUK (0.33) | SMN1; SMN2TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL1616084 | 0.78 | — | — | |
| SCHEMBL972563 | 0.78 | KDM4E (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |