SCHEMBL3949534

SCHEMBL3949534

CC(=O)CC(=O)Nc1cccc(F)c1F

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.51
ALPL P05186 1/20 0.51
ALPI P09923 1/20 0.51
ALPG P10696 1/20 0.51
SMN1; SMN2 Q16637 4/20 0.49
MAPT P10636 3/20 0.45
POLB P06746 1/20 0.45
GAA P10253 1/20 0.45
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
LMNA P02545 1/20 0.43
HTT P42858 1/20 0.43
PKM P14618 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
TSHR P16473 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3990399 0.86 SMN1; SMN2 (0.60) ALDH1A1ALPLALPIALPGSMN1; SMN2
SCHEMBL17509823 0.83 ALDH1A1 (0.49) ALDH1A1SMN1; SMN2MAPTGAARAB9A
SCHEMBL30368335 0.82 ALDH1A1 (0.52) ALDH1A1ALPLALPIALPGSMN1; SMN2
SCHEMBL1430696 0.82 ALDH1A1 (0.52) ALDH1A1ALPLALPIALPGSMN1; SMN2
SCHEMBL31365394 0.81 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2MAPTPOLBGAA
SCHEMBL26607674 0.81 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2MAPTPOLBGAA
SCHEMBL2795240 0.81 ALDH1A1 (0.49) ALDH1A1ALPLALPIALPGSMN1; SMN2
SCHEMBL2187600 0.81 ALPL (0.49) ALDH1A1ALPLALPIALPGSMN1; SMN2
SCHEMBL16332165 0.80 KMT2A (0.51) ALDH1A1MAPTLMNAHTTMEN1
SCHEMBL3956096 0.80 ALPL (0.46) ALDH1A1ALPLALPIALPGSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009029617-A1 DIARYLAMINE-SUBSTITUTED QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS KALYPSYS, INC. (US) 2009-03-05 WO disclosed
WO-2009029625-A1 4- [HETEROCYCLYL-METHYL] -8-FLUORO-QUINOLIN-2-ONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS KALYPSYS, INC. (US) 2009-03-05 WO disclosed
WO-2009029625-A1 4- [HETEROCYCLYL-METHYL] -8-FLUORO-QUINOLIN-2-ONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS KALYPSYS, INC. (US) 2009-03-05 WO disclosed
WO-2009029592-A1 HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS KALYPSYS, INC. (US) 2009-03-05 WO disclosed
WO-2009029617-A1 DIARYLAMINE-SUBSTITUTED QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS KALYPSYS, INC. (US) 2009-03-05 WO disclosed
WO-2009029592-A1 HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS KALYPSYS, INC. (US) 2009-03-05 WO disclosed