SCHEMBL3949786

SCHEMBL3949786

Clc1ccc(-c2nc(-c3nc(-c4ccc(Cl)cc4Cl)c(-c4ccc(Cl)cc4Cl)[nH]3)[nH]c2-c2ccc(Cl)cc2Cl)c(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GUSB P08236 1/20 0.43
NPBWR1 P48145 1/20 0.43
CRHR1 P34998 1/20 0.42
MAPT P10636 2/20 0.42
HPGD P15428 1/20 0.42
DPP4 P27487 4/20 0.41
MAPK13 O15264 2/20 0.40
MAPK12 P53778 2/20 0.40
MAPK11 Q15759 2/20 0.40
MAPK14 Q16539 2/20 0.40
RAF1 P04049 1/20 0.40
AHR P35869 1/20 0.40
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
TP53 P04637 1/20 0.40
CYP3A4 P08684 1/20 0.40
HSD11B1 P28845 1/20 0.40
CXCR2 P25025 1/20 0.39
IDO1 P14902 1/20 0.39
ALDH1A1 P00352 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7041005 0.83 HSD11B1 (0.45) CRHR1MAPTHPGDDPP4HSP90AA1
SCHEMBL14991718 0.76 GUSB (0.38) GUSBCRHR1DPP4MAPK13MAPK12
SCHEMBL29098442 0.76 GUSB (0.51) GUSBNPBWR1CRHR1MAPTHPGD
SCHEMBL28397228 0.76 MAPK13 (0.70) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL8791817 0.75 MAPK14 (0.60) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL24043881 0.75 MAPK13 (0.60) MAPTHPGDMAPK13MAPK12MAPK11
SCHEMBL2948138 0.74 MAPK13 (0.58) GUSBMAPTMAPK13MAPK12MAPK11
SCHEMBL28398756 0.74 MAPK13 (0.45) GUSBMAPTHPGDDPP4MAPK13
SCHEMBL28398011 0.74 IDO1 (0.50) GUSBMAPTHPGDDPP4MAPK13
SCHEMBL14060795 0.73 MAPK13 (0.50) MAPTHPGDDPP4MAPK13MAPK12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009024592-A1 PROCESSING OF LITHOGRAPHIC PRINTING PLATES WITH A DEVELOPER SOLUTION CONTAINING A HYDROPHILIC POLYMER EASTMAN KODAK COMPANY (US) 2009-02-26 WO disclosed