Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.53 |
| ▸ | GUSB | P08236 | 6/20 | 0.48 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714645 | 0.80 | EGFR (0.60) | EGFRCHEK1GUSBALDH1A1CYP2C19 | |
| SCHEMBL29986893 | 0.76 | EGFR (1.00) | EGFRALDH1A1 | |
| SCHEMBL725160 | 0.76 | EGFR (1.00) | EGFRALDH1A1 | |
| SCHEMBL13680616 | 0.76 | EGFR (0.51) | EGFRCHEK1GUSBCYP2C9CA12 | |
| SCHEMBL17136835 | 0.75 | SCN9A (0.51) | PI4K2AARSCN9ACA12CA1 | |
| SCHEMBL3538991 | 0.74 | CHEK1 (0.51) | EGFRCHEK1GUSBALDH1A1 | |
| SCHEMBL5326402 | 0.73 | MAPT (0.62) | CHEK1ALDH1A1 | |
| SCHEMBL1785268 | 0.73 | HTR2B (0.59) | HTR2BACHEALDH1A1CYP2C19 | |
| SCHEMBL1249544 | 0.72 | RAB9A (0.66) | HTR2BACHEALDH1A1CYP2C19 | |
| SCHEMBL999473 | 0.72 | HDAC1 (0.69) | HTR2BACHEALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010508-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120096-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |