Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639992 | 0.67 | MAPT (0.48) | ALDH1A1MAPTMMP2MMP9CYP2C9 | |
| SCHEMBL17294198 | 0.65 | MAPT (0.46) | ALDH1A1MAPTMMP2MMP9CYP2C9 | |
| SCHEMBL7003557 | 0.62 | ALDH1A1 (0.53) | ALDH1A1MAPTMMP2MMP9CYP2C9 | |
| SCHEMBL2163156 | 0.62 | ALDH1A1 (0.53) | ALDH1A1MAPTMMP2MMP9KDM4C | |
| SCHEMBL17276389 | 0.62 | BRD4 (0.39) | ALDH1A1MAPTEHMT2EHMT1BBOX1 | |
| SCHEMBL320007 | 0.62 | HSD17B10 (0.53) | ALDH1A1MAPTCA2HSD17B10KMT2A | |
| SCHEMBL472476 | 0.62 | KDM4C (0.51) | ALDH1A1MAPTMMP2MMP9KDM4C | |
| SCHEMBL11366355 | 0.62 | CRBN (0.43) | ALDH1A1MAPTMMP2MMP9KDM4C | |
| SCHEMBL29079991 | 0.62 | POLB (0.40) | ALDH1A1MEN1KMT2AGAATSHR | |
| SCHEMBL16597881 | 0.61 | MAPT (0.55) | ALDH1A1MAPTMMP9CYP2C9KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100367-A2 | COMPOSITIONS COMPRISING TOPICAL DPD INHIBITORS AND METHODS OF USING SAME IN THE TREATMENT OF HAND-FOOT SYNDROME | ADHEREX TECHNOLOGIES INC. (CA) | 2009-08-13 | — | — | WO | claimed |
| US-20090196833-A1 | COMPOSITIONS COMPRISING TOPICAL DPD INHIBITORS AND METHODS OF USING SAME IN THE TREATMENT OF HAND-FOOT SYNDROME | ADHEREX TECHNOLOGIES INC. (CA) | 2009-08-06 | — | — | US | claimed |
| US-20080255168-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (CA) | 2008-10-16 | — | — | US | claimed |
| EP-1827443-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | Adherex Technologies, Inc. (CA) | 2007-09-05 | — | — | EP | claimed |
| WO-2006060697-A9 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES INC (CA) | 2006-09-21 | — | — | WO | claimed |
| US-20060148753-A1 | Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs | ADHEREX TECHNOLOGIES, INC. (CA) | 2006-07-06 | — | — | US | claimed |
| WO-2006060697-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (CA) | 2006-06-08 | — | — | WO | claimed |
| US-RE37623-E1 | PHENYLTHIO AND PHENYLSELENO PYRIMIDINE ANALOGS | el Kouni, Mahmoud H. | 2002-04-02 | — | — | US | claimed |
| EP-0725641-B1 | NOVEL INHIBITORS OF URIDINE PHOSPHORYLASE (UrdPase) AND DIHYDROURACIL DEHYDROGENASE (DHUDase) | EL KOUNI MAHMOUD H (US) | 2000-12-13 | — | — | EP | claimed |
| US-5721241-A | PYRIMIDINE COMPOUND USEFUL TO DISRUPT VIRAL, CANCER, FUNGAL, PARASITE OR BACTERIAL REPLICATION AND DIHYDROURACIL DEHYDROGENASE OR URIDINE PHOSPHORYLASE INHIBITORS | el Kouni, Mahmoud H. (US) | 1998-02-24 | — | — | US | claimed |
| EP-0725641-A4 | — | — | 1996-09-04 | — | — | EP | claimed |
| EP-0725641-A1 | NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE | El Kouni, Mahmoud H. (US) | 1996-08-14 | — | — | EP | claimed |
| US-5476855-A | Pyrimidine analogs and nucleosides | el Kouni, Mahmoud H. (US) | 1995-12-19 | — | — | US | claimed |
| WO-1995012400-A1 | NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE | UAB RESEARCH FOUNDATION (US) | 1995-05-11 | — | — | WO | claimed |
| US-20130184232-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | SPECTOR THOMAS (US) | 2013-07-18 | — | — | US | disclosed |
| US-8318756-B2 | Dihydropyrimidine dehydrogenase (DPD) inhibitors; 5-fluorouracil; anticancer | ADHEREX TECHNOLOGIES, INC. (CA) | 2012-11-27 | — | — | US | disclosed |
| US-20080255168-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (CA) | 2008-10-16 | — | — | US | disclosed |
| EP-0725641-A1 | NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE | El Kouni, Mahmoud H. (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5476855-A | Pyrimidine analogs and nucleosides | el Kouni, Mahmoud H. (US) | 1995-12-19 | — | — | US | disclosed |
| WO-1995012400-A1 | NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE | UAB RESEARCH FOUNDATION (US) | 1995-05-11 | — | — | WO | disclosed |