SCHEMBL395217

SCHEMBL395217

C=Cc1ccc(C(=O)N2CCN(C)CC2)cc1

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.63
HPGD P15428 6/20 0.59
ALOX15 P16050 1/20 0.59
KMT2A Q03164 3/20 0.56
MEN1 O00255 2/20 0.56
CYP1A2 P05177 1/20 0.56
CYP2D6 P10635 1/20 0.56
CYP2C19 P33261 1/20 0.56
GRM5 P41594 1/20 0.55
TSHR P16473 1/20 0.53
HRH3 Q9Y5N1 2/20 0.52
LMNA P02545 1/20 0.52
EPHX2 P34913 1/20 0.51
NPC1 O15118 1/20 0.51
L3MBTL3 Q96JM7 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
APP P05067 1/20 0.48
CYP2C9 P11712 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10724841 0.86 POLB (0.81) POLBHPGDALOX15KMT2AMEN1
SCHEMBL4392112 0.85 POLB (0.65) POLBHPGDALOX15KMT2AMEN1
SCHEMBL8140738 0.83 ALDH1A1 (0.47) POLBHPGDKMT2AMEN1LMNA
SCHEMBL4900673 0.83 HPGD (0.71) HPGDKMT2AMEN1TSHRLMNA
SCHEMBL3654186 0.81 HPGD (0.55) POLBHPGDKMT2AMEN1CYP1A2
SCHEMBL5592684 0.81 POLB (0.69) POLBHPGDALOX15KMT2AMEN1
SCHEMBL20449050 0.80 POLB (0.86) POLBHPGDALOX15KMT2AMEN1
SCHEMBL4906405 0.80 PHGDH (0.63) POLBHPGDKMT2ATSHREPHX2
SCHEMBL7748545 0.80 POLB (0.59) POLBHPGDALOX15KMT2AMEN1
SCHEMBL7748548 0.80 POLB (0.59) POLBHPGDALOX15KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1551885-B1 PROCESS TO MODIFY POLYMERIC MATERIALS 3M INNOVATIVE PROPERTIES CO (US) 2016-02-17 EP disclosed
US-8101711-B2 Process to modify polymeric materials and resulting compositions 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-01-24 US disclosed
US-20100048819-A1 PROCESS TO MODIFY POLYMERIC MATERIALS AND RESULTING COMPOSITIONS 3M INNOVATIVE PROPERTIES COMPANY 2010-02-25 US disclosed
US-7632916-B2 Thermally induced graft polymerization in an apparatus by shearing, devolatilization; grafting isoprene-t-butyl methacrylate copolymer with polyoxyethylene glycol methyl ether, forming methacrylic acid/anhydride monomers 3M INNOVATIVE PROPERTIES COMPANY (US) 2009-12-15 US disclosed
US-20070122915-A1 Continuous process for the production of combinatorial libraries of modified materials 3M INNOVATIVE PROPETIES COMPANY 2007-05-31 US disclosed
US-7157283-B2 Continuous process for the production of combinatorial libraries of modified materials 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-01-02 US disclosed
EP-1551885-A2 PROCESS TO MODIFY POLYMERIC MATERIALS AND RESULTING COMPOSITIONS 3M Innovative Properties Company (US) 2005-07-13 EP disclosed
EP-1551547-A1 A CONTINUOUS PROCESS FOR THE PRODUCTION OF COMBINATORIAL LIBRARIES OF MODIFIED MATERIALS 3M Innovative Properties Company (US) 2005-07-13 EP disclosed
WO-2004012858-A1 A CONTINUOUS PROCESS FOR THE PRODUCTION OF COMBINATORIAL LIBRARIES OF MODIFIED MATERIALS 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-02-12 WO disclosed
WO-2004013189-A2 PROCESS TO MODIFY POLYMERIC MATERIALS AND RESULTING COMPOSITIONS 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-02-12 WO disclosed
US-20040023398-A1 Continuous process for the production of combinatorial libraries of modified materials 3M INNOVATIVE PROPERTIES COMPANY 2004-02-05 US disclosed
US-20040024130-A1 Process to modify polymeric materials and resulting compositions 3M INNOVATIVE PROPERTIES COMPANY 2004-02-05 US disclosed