Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | POLB | P06746 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9021687 | 0.75 | CYP2E1 (0.44) | CYP2E1CYP3A4CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL624039 | 0.75 | PIK3CA (0.55) | CYP2E1CYP3A4CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL12571323 | 0.73 | CYP3A4 (0.57) | CYP2E1CYP3A4CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL28603182 | 0.72 | NPC1 (0.41) | CYP2E1CYP3A4CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL823936 | 0.71 | ALDH1A1 (0.46) | CYP2E1CYP3A4CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL1108276 | 0.71 | CYP2E1 (0.43) | CYP2E1CYP3A4CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL14395269 | 0.70 | CYP2E1 (0.49) | CYP2E1CYP3A4CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL14324626 | 0.70 | ALDH1A1 (0.60) | CYP2E1CYP3A4CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL833371 | 0.70 | KDM4E (0.48) | CYP2C19ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL6656195 | 0.70 | ALDH1A1 (0.61) | CYP2E1CYP3A4CYP2D6CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188121-B2 | Substituted pyridines as antiparasitic AZA teraryl compounds | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-05-29 | — | — | US | disclosed |
| US-8101636-B2 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-01-24 | — | — | US | disclosed |
| US-20110257199-A1 | NOVEL TERARYL COMPOUNDS AS ANTIPARASITIC AGENTS | TIDWELL RICHARD R | 2011-10-20 | — | — | US | disclosed |
| US-7964619-B2 | Teraryl components as antiparasitic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2011-06-21 | — | — | US | disclosed |
| EP-1949896-A2 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | The University of North Carolina At Chapel Hill (US) | 2008-07-30 | — | — | EP | disclosed |
| US-20070232621-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2007-10-04 | — | — | US | disclosed |
| CN-1990477-A | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | UNIV NORTH CAROLINA CHAPEL HILL (US) | 2007-07-04 | — | — | CN | disclosed |
| US-20060293328-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TIDWELL RICHARD R | 2006-12-28 | — | — | US | disclosed |
| EP-1736466-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | The University of North Carolina at Chapel Hill (US) | 2006-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232621-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TPMT, TYMS, DDT | CYP2E1 1362/4885CYP3A4 69/4885CYP2D6 480/4885 |
| US-20110257199-A1 | NOVEL TERARYL COMPOUNDS AS ANTIPARASITIC AGENTS | DDT, ZC3HAV1, MAVS | CYP2E1 777/4885CYP3A4 86/4885CYP2D6 677/4885 |
| US-20060293328-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TPMT, TYMS, DDT | CYP2E1 1362/4885CYP3A4 69/4885CYP2D6 480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.