Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 10/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 10/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3961647 | 0.92 | GFER (0.44) | GFERKCNK3KCNK9ALDH1A1L3MBTL1 | |
| SCHEMBL3961800 | 0.91 | AGTR1 (0.43) | GFERKCNK3KCNK9ALDH1A1L3MBTL1 | |
| SCHEMBL3958607 | 0.91 | GFER (0.45) | GFERKCNK3KCNK9ALDH1A1L3MBTL1 | |
| SCHEMBL5128972 | 0.89 | KCNK3 (0.46) | GFERKCNK3KCNK9ALDH1A1L3MBTL1 | |
| SCHEMBL5128969 | 0.89 | KCNK3 (0.46) | GFERKCNK3KCNK9ALDH1A1L3MBTL1 | |
| SCHEMBL3959499 | 0.87 | GFER (0.51) | GFERKCNK3KCNK9ALDH1A1L3MBTL1 | |
| SCHEMBL3961045 | 0.86 | GFER (0.49) | GFERKCNK3KCNK9KMT2ANPC1 | |
| SCHEMBL3960282 | 0.86 | GFER (0.47) | GFERKCNK3KCNK9ALDH1A1L3MBTL1 | |
| SCHEMBL3955085 | 0.85 | GFER (0.49) | GFERKCNK3KCNK9ALDH1A1L3MBTL1 | |
| SCHEMBL3963579 | 0.85 | AGTR1 (0.44) | GFERKCNK3KCNK9ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079737-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008097991-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-14 | — | — | WO | disclosed |