Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 4/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3961800 | 0.95 | AGTR1 (0.43) | GFERAGTR1AGTR2MAPTKMT2A | |
| SCHEMBL3963579 | 0.90 | AGTR1 (0.44) | GFERAGTR1AGTR2MAPTKMT2A | |
| SCHEMBL3961647 | 0.90 | GFER (0.44) | GFERAGTR1AGTR2MAPTKMT2A | |
| SCHEMBL3965651 | 0.89 | GFER (0.45) | GFERAGTR1AGTR2MAPTKCNK3 | |
| SCHEMBL3963510 | 0.89 | GFER (0.45) | GFERAGTR1AGTR2MAPTKCNK3 | |
| SCHEMBL3958607 | 0.87 | GFER (0.45) | GFERKMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL3958495 | 0.86 | AGTR1 (0.40) | GFERAGTR1AGTR2MAPTKMT2A | |
| SCHEMBL14138384 | 0.86 | ADORA1 (0.45) | AGTR1AGTR2MAPTNPC1RAB9A | |
| SCHEMBL3953208 | 0.86 | GFER (0.47) | GFERKMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL5121930 | 0.85 | MAPT (0.41) | GFERAGTR1AGTR2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079737-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2009-07-22 | — | — | EP | claimed |
| WO-2008097991-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-14 | — | — | WO | claimed |
| EP-2079737-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008097991-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-14 | — | — | WO | disclosed |