Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5751035 | 0.85 | CYP2A6 (0.52) | SLC6A4SLC6A2SLC6A3ALDH1A1KDM4E | |
| SCHEMBL3556399 | 0.83 | CYP2A6 (0.50) | SLC6A4SLC6A2SLC6A3ALDH1A1KDM4E | |
| SCHEMBL12320515 | 0.82 | TYMS (0.44) | TYMSNQO2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL29595200 | 0.79 | CYP2A6 (0.52) | TYMSALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL1569370 | 0.79 | CYP2A6 (0.52) | TYMSALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL8637909 | 0.74 | AKR1C3 (0.52) | TYMSNQO2MTNR1AMTNR1BSLC6A4 | |
| SCHEMBL29740644 | 0.74 | AKR1C3 (0.52) | TYMSNQO2MTNR1AMTNR1BSLC6A4 | |
| SCHEMBL12278775 | 0.73 | CYP1A2 (0.44) | TYMSNQO2MTNR1AMTNR1BSLC6A4 | |
| SCHEMBL12268990 | 0.73 | ALDH1A1 (0.44) | TYMSNQO2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL22652971 | 0.72 | NQO2 (0.39) | TYMSNQO2MTNR1AMTNR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286772-A1 | 2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles | MERCK & CO., INC. | 2009-11-19 | — | — | US | disclosed |
| EP-1989187-A4 | 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO (9,10-D) IMIDAZOLES | MERCK FROSST CANADA LTD (CA) | 2009-07-08 | — | — | EP | disclosed |
| EP-1989187-A1 | 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO (9,10-D) IMIDAZOLES | Merck Frosst Canada Ltd. (CA) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007095753-A1 | 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO [9,10-D] IMIDAZOLES | MERCK FROSST CANADA LTD. (CA) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286772-A1 | 2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles | PTGES, PTGS1, PTGES2 | TYMS 1515/4885NQO2 211/4885MTNR1A 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.