Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ME3 | Q16798 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959612 | 0.85 | KMT2A (0.49) | SMN1; SMN2ALDH1A1TSHRMAPTMEN1 | |
| SCHEMBL13906609 | 0.85 | MEN1 (0.49) | SMN1; SMN2ALDH1A1TSHRMAPTMEN1 | |
| SCHEMBL3958384 | 0.84 | DRD4 (0.56) | DRD4MEN1KMT2AME3ACHE | |
| SCHEMBL458122 | 0.84 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL377924 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1TSHRMAPTMEN1 | |
| SCHEMBL2293847 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1MAPTNAMPTALOX15 | |
| SCHEMBL2293851 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1MAPTNAMPTALOX15 | |
| SCHEMBL3958170 | 0.81 | ALDH1A1 (0.60) | SMN1; SMN2ALDH1A1TSHRMAPTMEN1 | |
| SCHEMBL7324645 | 0.81 | BCHE (0.56) | SMN1; SMN2ALDH1A1TSHRMAPTGAA | |
| SCHEMBL3954451 | 0.80 | BCL2 (0.51) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036035-A1 | BCL-2 INHIBITORS | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009036035-A1 | BCL-2 INHIBITORS | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |