Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 12/20 | 0.59 |
| ▸ | CYP1B1 | Q16678 | 12/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954756 | 1.00 | CYP1A1 (0.59) | CYP1A1CYP1B1CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL13790243 | 0.88 | CYP1A1 (0.71) | CYP1A1CYP1B1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL7567897 | 0.88 | CYP1A1 (0.71) | CYP1A1CYP1B1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL8367958 | 0.88 | CYP1A1 (0.71) | CYP1A1CYP1B1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL13790333 | 0.88 | CYP1A1 (0.71) | CYP1A1CYP1B1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL116401 | 0.85 | — | — | |
| SCHEMBL8588523 | 0.83 | CYP2A6 (0.47) | ALDH1A1MEN1KMT2A | |
| SCHEMBL13430073 | 0.81 | CYP2C19 (0.48) | CYP1A1CYP1B1CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL2577996 | 0.80 | ALDH1A1 (0.61) | CYP1B1ALDH1A1CYP2C19KDM4EHPGD | |
| SCHEMBL9679607 | 0.80 | ALDH1A1 (0.61) | CYP1B1ALDH1A1CYP2C19KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286772-A1 | 2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles | MERCK & CO., INC. | 2009-11-19 | — | — | US | disclosed |
| EP-1989187-A4 | 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO (9,10-D) IMIDAZOLES | MERCK FROSST CANADA LTD (CA) | 2009-07-08 | — | — | EP | disclosed |
| EP-1989187-A1 | 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO (9,10-D) IMIDAZOLES | Merck Frosst Canada Ltd. (CA) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007095753-A1 | 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO [9,10-D] IMIDAZOLES | MERCK FROSST CANADA LTD. (CA) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286772-A1 | 2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles | PTGES, PTGS1, PTGES2 | CYP1A1 13/4885CYP1B1 16/4885CYP1A2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.