Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.38 |
| ▸ | LDHB | P07195 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL437501 | 1.00 | CDK2 (0.43) | CDK2CCNE2CCNE1ERN1CCNT1 | |
| SCHEMBL3955501 | 0.82 | MAPK14 (0.54) | CDK2CCNE2CCNE1ERN1CCNT1 | |
| SCHEMBL397514 | 0.82 | ALOX5AP (0.45) | PDK2MAPK14TRPV1CHEK1LCK | |
| SCHEMBL435776 | 0.78 | CDK2 (0.45) | CDK2CCNE2CCNE1ERN1CCNT1 | |
| SCHEMBL439662 | 0.78 | CDK2 (0.45) | CDK2CCNE2CCNE1ERN1CCNT1 | |
| SCHEMBL436516 | 0.78 | CDK2 (0.45) | CDK2CCNE2CCNE1ERN1CCNT1 | |
| SCHEMBL436517 | 0.75 | PDK2 (0.43) | CDK2CCNE2CCNE1ERN1CCNT1 | |
| SCHEMBL396560 | 0.74 | MAPK14 (0.55) | MAP3K5LDHBMAPK14MAPK13ABL1 | |
| SCHEMBL397201 | 0.74 | NPC1 (0.45) | KDR | |
| SCHEMBL395778 | 0.72 | MAPK14 (0.55) | MAPK14ABL1LCKLYNKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101612-B2 | N-3-isoxazolyl-4-methyl-3-(1-((1-methylethyl)oxy)-6-phthalazinyl)benzamide; p38 kinase inhibitor; antiinflammatory, analgesic agent; rheumatoid arthritis, osteoporosis, leukemia, psoriasis, Crohn's disease, rhinitis, ulcerative colitis, dermatitis, asthma, Alzheimer's disease, type I and II diabetes | AMGEN INC. (US) | 2012-01-24 | — | — | US | disclosed |