Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | WNT1 | P04628 | 2/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | ANPEP | P15144 | 2/20 | 0.53 |
| ▸ | KDM5A | P29375 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30365687 | 1.00 | ALDH1A1 (0.62) | ALDH1A1L3MBTL1MAPTRAB9AHTT | |
| SCHEMBL10224770 | 0.93 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1MAPTRAB9AHTT | |
| SCHEMBL357738 | 0.93 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1MAPTRAB9AHTT | |
| SCHEMBL28683089 | 0.91 | SMN1; SMN2 (0.59) | ALDH1A1L3MBTL1MAPTRAB9AHTT | |
| SCHEMBL1116630 | 0.87 | ALDH1A1 (0.78) | ALDH1A1L3MBTL1MAPTRAB9AHTT | |
| SCHEMBL14082548 | 0.86 | DYRK1A (0.63) | RAB9ASMN1; SMN2WNT1DYRK1AKMT2A | |
| SCHEMBL10212594 | 0.85 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1MAPTRAB9AHTT | |
| SCHEMBL8863594 | 0.85 | ALDH1A1 (0.64) | ALDH1A1L3MBTL1MAPTRAB9AHTT | |
| SCHEMBL3427705 | 0.84 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1MAPTRAB9AHTT | |
| SCHEMBL3427969 | 0.84 | ALDH1A1 (0.70) | ALDH1A1L3MBTL1MAPTRAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |