Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL28307095 | 0.98 | HCAR2 (0.65) | HCAR2LMNAALDH1A1THRBAKR1B10 | |
| SCHEMBL28230354 | 0.98 | HCAR2 (0.65) | HCAR2LMNAALDH1A1THRBAKR1B10 | |
| SCHEMBL34054 | 0.98 | HCAR2 (0.65) | HCAR2LMNAALDH1A1THRBAKR1B10 | |
| SCHEMBL11696680 | 0.96 | HCAR2 (0.62) | HCAR2LMNAALDH1A1THRBAKR1B10 | |
| Hydrochloric Acid SCHEMBL28804358 | 0.96 | HCAR2 (0.62) | HCAR2LMNAALDH1A1THRBAKR1B10 | |
| Ammonia Solution, Strong SCHEMBL11584311 | 0.96 | HCAR2 (0.62) | HCAR2LMNAALDH1A1THRBAKR1B10 | |
| Ethylene SCHEMBL6402744 | 0.96 | HCAR2 (0.62) | HCAR2LMNAALDH1A1THRBAKR1B10 | |
| SCHEMBL8767252 | 0.96 | HCAR2 (0.62) | HCAR2LMNAALDH1A1THRBAKR1B10 | |
| Methane SCHEMBL28851569 | 0.96 | HCAR2 (0.62) | HCAR2LMNAALDH1A1THRBAKR1B10 | |
| Bromide SCHEMBL28618019 | 0.96 | HCAR2 (0.62) | HCAR2LMNAALDH1A1THRBAKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498394-B2 | (Meth)acrylic and (meth)acrylamide monomers, polymerizable compositions, and polymers obtained | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2009-03-03 | — | — | US | disclosed |
| US-20060252900-A1 | (Meth)arcrylic and (meth)acrylamide monomers, polymerizable compositions, and polymers obtained | REGENTS OF THE UNIVERSITY OF COLORADO, THE | 2006-11-09 | — | — | US | disclosed |
| WO-2004077511-A2 | (METH)ACRYLIC AND (METH)ACRYLAMIDE MONOMERS, POLYMERIZABLE COMPOSITIONS, AND POLYMERS OBTAINED | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2004-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252900-A1 | (Meth)arcrylic and (meth)acrylamide monomers, polymerizable compositions, and polymers obtained | MMAB, MAT1A, MAT2A | HCAR2 581/4885LMNA 4478/4885ALDH1A1 396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.