Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | LTK | P29376 | 1/20 | 0.53 |
| ▸ | GRK5 | P34947 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7108873 | 0.84 | SMN1; SMN2 (0.69) | RAB9AMEN1KMT2AMAPTGAA | |
| SCHEMBL18235580 | 0.81 | NPC1 (0.69) | RAB9AMEN1KMT2AMAPTGAA | |
| SCHEMBL3477398 | 0.81 | FAAH (0.58) | RAB9AMEN1KMT2AMAPTGAA | |
| SCHEMBL12749660 | 0.81 | MEN1 (0.62) | RAB9AMEN1KMT2AMAPTGAA | |
| SCHEMBL3949035 | 0.80 | NPC1 (0.71) | RAB9AMEN1KMT2AMAPTGAA | |
| SCHEMBL19029283 | 0.79 | HDAC6 (0.72) | RAB9AMEN1KMT2AMAPTGAA | |
| SCHEMBL2658434 | 0.78 | NPC1 (1.00) | RAB9AMEN1KMT2AMAPTGAA | |
| SCHEMBL7907992 | 0.78 | NPC1 (0.69) | RAB9AMEN1KMT2AMAPTGAA | |
| SCHEMBL11385434 | 0.78 | NPC1 (0.63) | RAB9AMEN1KMT2AMAPTGAA | |
| SCHEMBL18233034 | 0.78 | NPC1 (0.63) | RAB9AMEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915255-B2 | Metabolism-modulating agents and uses therefor | VERVA PHARMACEUTICALS PTY LTD (AU) | 2011-03-29 | — | — | US | disclosed |
| US-7915255-B2 | Metabolism-modulating agents and uses therefor | VERVA PHARMACEUTICALS PTY LTD (AU) | 2011-03-29 | — | — | US | disclosed |
| WO-2009029617-A1 | DIARYLAMINE-SUBSTITUTED QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |